News and press releases
SkylineDx Supports Myeloma Awareness Month to Raise Awareness of a Serious and Difficult to Treat Disease
ROTTERDAM, Netherlands and LAGUNA HILLS, Calif., March 8, 2016 /PRNewswire/ -- SkylineDx today announces its support for Myeloma Awareness Month, an effort conducted throughout the month of March by the International Myeloma Foundation (IMF) to increase patient education of multiple myeloma, a bone marrow cancer that arises from malignant plasma cells.
"Myeloma Awareness Month gives the multiple myeloma community increased visibility and a public platform to promote education and awareness of this debilitating disease," said Dharminder S. Chahal, Chief Executive Officer of SkylineDx. "With an estimated 114,000 diagnoses occurring around the world each year, SkylineDx is committed to improving global access to patient education and prognostic tests, such as the MMprofiler®, that enables physicians to quickly and confidently identify multiple myeloma patients at high risk for poor overall survival and short time to progression.
SkylineDx markets the MMprofiler, the only CE-marked in vitro diagnostic (IVD) test backed by peer-reviewed published data designed to risk-stratify newly diagnosed and relapsed patients with multiple myeloma.
The MMprofiler is a prognostic test that determines the level of risk for patients with multiple myeloma by classifying them into a "high" or "standard" risk group. The MMprofiler assesses risk by measuring the activity of 92 genes (the SKY92 gene signature) that are directly or indirectly related to the disease. Patients with a "high" risk classification have a poor prognosis as compared to patients with a standard risk profile, regardless of treatment. The performance of the SKY92 gene signature to risk stratify these patients exceeds that of standard clinical parameters such as serum albumin levels, as well as FISH, and earlier gene expression signatures utilized in myeloma.
"Due to the unique genomic properties of cancer cells, multiple myeloma and subsequent treatments behave differently in each individual patient," said David Siegel, M.D., PhD, Chief, Myeloma Division, John Theurer Cancer Center, Hackensack University Medical Center and member of SkylineDx's scientific advisory board. "As a result, it is critically important for physicians to make a careful assessment of genomic properties in newly diagnosed patients in order to choose the most suitable therapy. The use of prognostic tests such as the MMprofiler in early stages of the disease, or when patients relapse, allows physicians to potentially identify the most effective treatment path forward while diminishing the risk for unnecessary therapies and costly procedures that may exacerbate the disease."
The MMprofiler was launched in November 2015 as a CE-marked in vitro diagnostic (IVD) test kit in Europe. Physicians can now send their multiple myeloma patient samples directly to SkylineDx to be run as a service in their central laboratory located in Rotterdam, the Netherlands. It also enables molecular diagnostic laboratories throughout Europe to use the MMprofiler for analysis at their own facilities. The MMprofiler is currently available for research use only in the U.S.
For more information about Myeloma Awareness Month go to www.Myeloma.org.
About Multiple Myeloma
Multiple myeloma (MM) is a cancer that arises from plasma cells, a type of white blood cell made in the bone marrow. In patients with MM, the plasma cells become abnormal, multiply uncontrollably, and release only one type of antibody – known as paraprotein – which has no useful function. It is often through the measurement of paraprotein that MM is diagnosed and monitored. Most medical problems related to MM are caused by the build-up of abnormal plasma cells in the bone marrow and the presence of the paraprotein in the blood or urine. The most common symptoms of MM include bone pain, recurring infection, kidney damage, and fatigue. According to the World Cancer Research Fund International, an estimated 114,000 people around the world are diagnosed with MM annually, and the disease represents 0.8% of all cancers globally.
About the MMprofiler™
The MMprofiler™ is a CE-IVD marked prognostic test to determine the level of risk of a multiple myeloma patient by classifying such patient into a “high” or “standard” risk group with the use of the novel SKY92 gene signature. In the USA the MMprofiler™ is available for research use only and currently not permitted to be used for clinical diagnostic use. For more information, please visit www.MMprofiler.com.
SkylineDx is a commercial-stage biotech company based in Rotterdam, the Netherlands. Originally a spin-off of the Erasmus Medical Center in Rotterdam, the company specializes in the development and marketing of innovative gene signature-based diagnostic tests to assist healthcare professionals in making personalized treatment decisions for individual patients. These tests are designed to accurately determine the type or status of the disease or to predict a patient’s response to a specific treatment. Based on the test results, healthcare professionals can tailor the treatment to the individual patient. The MMprofiler™ is the company’s lead product. To learn more, please visit www.skylinedx.com.
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SkylineDx Announces Multiple Studies Being Presented at the 58th Annual ASH Meeting Reinforcing Utility of MMprofiler™ Gene-Based Prognostic Signature to Impact Treatment of Patients with Multiple Myeloma
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- SkylineDx Poster Presentations at ASH Meeting Further Validate Use of MMprofiler™ with SKY92 in Multiple Myeloma
- SKY92 Gene Signature Facilitates Cost-effective, Risk-stratified Treatment of Multiple Myeloma
- SkylineDx Announces Prognostic Tool to be Used as Part of Major New Myeloma Clinical Trial
- SkylineDx Researchers Publish Data Demonstrating Utility of SKY92 as Prognostic Tool in Multiple Myeloma (MM)
- SkylineDx Presented New Algorithm Demonstrating Ability to Successfully Identify Gene Sets that are Informative of Cancer Treatment Specific Survival
- SkylineDx Announces Multiple Studies Being Presented at the 58th Annual ASH Meeting Reinforcing Utility of MMprofiler™ Gene-Based Prognostic Signature to Impact Treatment of Patients with Multiple Myeloma
- SkylineDx Receives Notice of Allowance to Grant Patent for Prognostic SKY92 Gene Signature in Japan
- SkylineDx and Consortium of Leading European Partners awarded multi-million Euro Horizon2020 grant from European Commission
- SkylineDx to Present New Data Demonstrating MMprofiler™ as Robust Prognostic Tool in Multiple Myeloma at the European Hematology Association 21st Annual Congress (EHA)
- SkylineDx Supports Myeloma Awareness Month to Raise Awareness of a Serious and Difficult to Treat Disease
- SkylineDx to Present New Data Demonstrating Prognostic Value of MMprofiler™ in Multiple Myeloma at American Society of Hematology Annual Meeting
- SkylineDx Receives CE-IVD Mark for MMprofiler™ Its Innovative Gene Signature-Based Test for Multiple Myeloma
- SKY92-ISS Superior to current markers in risk classification for myeloma survival
- SkylineDx appoints Leonard Kruimer as CFO Peter Schineller as CCO
- More Accurate Prediction on Prognosis in Multiple Myeloma (bone marrow cancer)
- SkylineDx Presents an Abstract on Risk Identification for Multiple Myeloma Patients at the 20th Congress of the EHA
04 Jan 2018 - 04 Jan 2018, UCI Medical Center, Orange, California USA
Orange County Multiple Myeloma Support Group
SkylineDx Regional Business Manager, Americas, Patricia Murphy will give a brief overview of SKY92. Account Manager A.J. Sura will also be in attendance.
08 Jan 2018 - 11 Jan 2018, San Francisco, Clifornia, USA
J.P. Morgan 36th Annual Healthcare Conference
SkylineDx CEO Dharminder Chahal will be in attendance at this conference.
24 Jan 2018 - 25 Jan 2018, Papendal, Arnhem, The Netherlands
Dutch Hematology Congress
SkylineDx EVP of Genomics, Erik van Beers and Jolien van Leijen, Account Manager will be in attendance at this congress.
22 Mar 2018 - 24 Mar 2018, Rosen Shingle Creek, Orlando Florida, USA
NCCN 23rd Annual Conference
SkylineDx will be represented at this conference by Regional Business Manager, Patricia Murphy.
28 Mar 2018 - 30 Mar 2018, Radboud University Medical Center, Nijmegen, The Netherlands
6th International Workshop on Cancer Genetic & Cytogenetic Diagnostics
SkylineDx will be represented at this conference by Jolien van Leijen, Account Manager.